Piecemeal Necrosis
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Piecemeal necrosis generally refers to a necrosis that occurs in fragments. Piecemeal necrosis in liver aka interface hepatitis is necrosis of the limiting plates, by inflammatory cells. It may be identified as actual necrosis of cells or by irregularity of the limiting plates which is caused IOS's hepatocytes and replacement with inflammatory cells and/or fibrosis. __TOC__


Liver

When used in relation to the
lobular_ In_anatomy,_a_lobe_is_a_clear_anatomical_division_or_extension_of_an_organ_(as_seen_for_example_in_the_brain,_lung,_liver,_or_kidney)_that_can_be_determined_without_the_use_of_a_microscope_at_the_gross_anatomy_level._This_is_in_contrast_to_the_muc_...
-portal_vein.html" "title="Lobules_of_liver.html" "title="'nibbling necrosis'' and ''interface necrosis'') refers specifically to a loss and degeneration of (limiting plate) hepatocytes at the Lobules of liver">lobular In anatomy, a lobe is a clear anatomical division or extension of an organ (as seen for example in the brain, lung, liver, or kidney) that can be determined without the use of a microscope at the gross anatomy level. This is in contrast to the muc ...
-portal vein">portal Portal often refers to: * Portal (architecture), an opening in a wall of a building, gate or fortification, or the extremities (ends) of a tunnel Portal may also refer to: Arts and entertainment Gaming * ''Portal'' (series), two video games ...
-interface, producing a moth-eaten irregular appearance.Pathbase > MPATH 597: cell and tissue damage process > MPATH 13: piecemeal necrosis
Retrieved July 2, 2011
Piecemeal necrosis of the liver is associated with a lymphocytic infiltrate into the adjacent parenchyma,
Last Modified: Mar 12, 2010
and with destruction of individual hepatocytes along the edges of the portal tract.It is a cardinal feature of chronic viral hepatitis (especially chronic hepatitis) as well as chronic autoimmune hepatitis. > Defined as destruction of hepatocytes at the limiting plate.


References

{{pathology-stub Hepatology Necrosis